HDXBoxeR: Analysis of Hydrogen-Deuterium Exchange Mass-Spectrometry Data
A protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis.
It provides a pipeline for analyzing data from 'HDXExaminer' (Sierra Analytics, Trajan Scientific),
automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework.
Additionally, it simplifies data export, generates 'Pymol' scripts, and ensures calculations meet publication standards.
'HDXBoxeR' assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides,
generating plots, and facilitating comparison between protein states.
For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325>
and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>.
| Version: |
0.0.1 |
| Imports: |
dplyr, graphics, grDevices, RColorBrewer, stats, stringr, tidyr, utils, methods, wrapr |
| Suggests: |
knitr, rmarkdown, testthat (≥ 3.0.0) |
| Published: |
2024-04-10 |
| Author: |
Maria K. Janowska 
[aut, cre],
Katherine Reiter [ctb],
Pearl Magala [ctb],
Miklos Guttman [ctb],
Rachel E. Klevit [ctb] |
| Maintainer: |
Maria K. Janowska <mka.janowska at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| Citation: |
HDXBoxeR citation info |
| Materials: |
README |
| CRAN checks: |
HDXBoxeR results |
Documentation:
Downloads:
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