Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).
|Depends:||R (≥ 3.1.2), methods|
|Imports:||Rcpp (≥ 0.12.3), dplyr (≥ 0.5.0), magrittr (≥ 1.5), lazyeval (≥ 0.1.10), RcppArmadillo (≥ 0.5.600.2.0), tibble (≥ 1.2)|
|LinkingTo:||Rcpp (≥ 0.12.1), RcppArmadillo (≥ 0.5.600.2.0), BH|
|Suggests:||lattice, testthat, XML, rmarkdown|
|Author:||Kyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph]|
|Maintainer:||Kyle T Baron <kyleb at metrumrg.com>|
|License:||GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]|
|Copyright:||Metrum Research Group, LLC 2017|
|CRAN checks:||mrgsolve results|
|Windows binaries:||r-devel: mrgsolve_0.8.6.zip, r-release: mrgsolve_0.8.6.zip, r-oldrel: mrgsolve_0.8.6.zip|
|OS X Mavericks binaries:||r-release: mrgsolve_0.8.6.tgz, r-oldrel: mrgsolve_0.8.6.tgz|
|Old sources:||mrgsolve archive|
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