The algorithm implemented in this package was designed to quickly estimates the distribution of the log-rank especially for heavy unbalanced groups. VALORATE estimates the null distribution and the p-value of the log-rank test based on a recent formulation. For a given number of alterations that define the size of survival groups, the estimation involves a weighted sum of distributions that are conditional on a co-occurrence term where mutations and events are both present. The estimation of conditional distributions is quite fast allowing the analysis of large datasets in few minutes <http://bioinformatica.mty.itesm.mx/valorate>.
|Depends:||R (≥ 3.1.0), methods|
|Imports:||survival, graphics, utils, stats|
|Author:||Victor Trevino [aut, cre]|
|Maintainer:||Victor Trevino <vtrevino at itesm.mx>|
|License:||GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]|
|CRAN checks:||valorate results|
|Windows binaries:||r-devel: valorate_1.0-1.zip, r-release: valorate_1.0-1.zip, r-oldrel: valorate_1.0-1.zip|
|OS X El Capitan binaries:||r-release: valorate_1.0-1.tgz|
|OS X Mavericks binaries:||r-oldrel: valorate_1.0-1.tgz|
|Old sources:||valorate archive|
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