Lifecycle: stable CRAN status Codecov test coverage R-CMD-check

scDiffCom stands for “single-cell Differential Communication” and infers changes in intercellular communication between two biological conditions from scRNA-seq data (as Seurat objects). The package relies on an internal collection of ligand-receptor interactions (available for human, mouse and rat) retrieved from seven curated databases.

Display LRI databases

* CellChat * CellPhoneDB * CellTalkDB * connectomeDB2020 * ICELLNET * NicheNet * SingleCellSignalR



# We currently highly recommend to install the development version from GitHub

# Install release version from CRAN


As an introduction, please look at the documentation and this vignette.

For a concrete and large-scale project that used scDiffCom, please look at, our murine atlas of age-related changes in intercellular communication.


Please consider reading and citing our Nature Aging paper: here.